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The first step in developing a differential diagnosis for patients with inflammatory eye disease is to
classify the uveitis in as detailed a fashion as possible.
This can be achieved by systematically asking the eight questions:
Is the disease acute or chronic?
Is the inflammation granulomatous or nongranulomatous?
Is the disease unilateral or bilateral?
Where is the inflammation located in the eye?
What are the demographics of the patient?
What associated symptoms does the patient have?
What associated signs are present on physical examination?
What is the time course of the disease and response to previous therapy?
Uveitis CLassifier Algorithm Questions
1. Acute or chronic?
2. Granulomatous or nongranulomatous?
3. Unilateral or bilateral?
4. Inflammation Location?
Posterior Uveitis - Focal Retinitis
Posterior Uveitis - Multifocal Retinitis
Posterior Uveitis - Focal Choroiditis
Posterior Uveitis - Multifocal Choroiditis
5-A. Patient Gender?
5-B. Patients Age Group?
Less than 5
5 - 15
16 - 25
26 - 45
46 - 65
Older than 65
History of trauma or surgery?
HLA B27 POS
HLA B27 NEG
HLA B51 POS
Anterior Segment Related Examination
Poliosis or Vitiligo
Salivary or Lacrimal Swelling
Assoicated with headache
New onset sensorineural deafness
CSF showing Pleocytosis
Paresthesia or Weakness
New onset Psychosis
Cough or Shortness of Breath
Kindly, select from the above options to generate related DDx
When needed, order the following baseline lab tests:
CBC, KFT, LFT
ANA, ANCA, RF
Q-Gold, FTA, CXR
Uveitis: Fundamentals and Clinical Practice (Fourth Edition)
Ocular Inflammatory Disease and Uveitis Manual: Diagnosis and Treatment (First Edition)
EyeWiki - American Academy of Ophthalmology
British Journal of Ophthalmology (BJO)
National Center for Biotechnology Information
This service aids the doctors generating DDx and not replacing their art of collecting evidence to weigh in or out certain diagnoses.
This is beta version: there are continuous modifications on the DDx alograthim. Feedback with examples are much appreciated.